Organic Synthesis Conditions Questions

  • Tab Title 1
  • Tab Title 2

For the following synthesis pathways, state the mechanism for each step and the conditions.

1.

2.

3.

4.

5.

6.

7.

8.

9.

For the following synthesis pathways, state the mechanism for each step and the conditions.

1.

Reaction 1: Electrophilic Addition / HCl, room temperature, no catalyst
Reaction 2: Nucleophilic Substitution / Excess NH3 dissolved in ethanol, heat

2.

Reaction 1: Nucleophilic substitution / NaOH dissolved in water (aqueous), heat under reflux.

Reaction 2: Oxidation / K2Cr2O7 (acidified), heat (not reflux)

3.

Reaction 1: Free Radical Substitution / Cl2, UV light

Reaction 2: Nucleophilic Substitution / KCN dissolved in a mixture and ethanol and water, heat under reflux.

4.

Reaction 1: Oxidation / K2Cr2O7 (acidified), heat (not reflux)

Reaction 2: Nucleophilic Addition / KCN and dilute H2SO4

5.

Reaction 1: Oxidation / K2Cr2O7 (acidified), heat under reflux

Reaction 2: Esterification / ethanol and concentrated sulfuric acid, heat

6.

Reaction 1: Nucleophilic Substitution / KCN dissolved in a mixture and ethanol and water, heat under reflux

Reaction 2: Reduction / LiAlH4 in dry ether or H2 and nickel catalyst

7.

Reaction 1: Electrophilic Substitution / Concentrated nitric acid and concentrated sulfuric acid.

Reaction 2: Reduction / Sn and HCl or Fe and HCl, heat

8.

Reaction 1: Elimination / potassium hydroxide or sodium hydroxide in ethanol, heat

Reaction 2: Addition or reduction / H2 and Ni catalyst

9.

Reaction` 1: Electrophilic Addition / chloromethane and AlCl3, warm

Reaction 2: Electrophilic Addition / Ethanoyl chloride and AlCl3, heat under reflux

[adinserter block=”1″]